BowTieBuilder

BowTieBuilder is a pathway reconstruction algorithm which constructs pathways in a ‘bowtie’-like fashion, finding the intersections of shortest paths between sources and targets and using those nodes as a basis for generating a new reconstructed network.

BowTieBuilder does not take in any arguments.

• Repository: https://github.com/Reed-CompBio/BowTieBuilder-Algorithm

• Paper: https://doi.org/10.1186/1752-0509-3-67

Dataset Usage

BowTieBuilder uses sources, targets, edge weights, and edge direction information.

Implementation Details

BowTieBuilder’s internal implementation only takes in directed interactomes. SPRAS will automatically convert edges to directed edges as necessary. For more information, see the section on algorithm directionality.